Glial Immune response to hazards in the brain in Parkinson’s Disease

Daily actions and thoughts emerge as cells in the central nervous system are constantly sending molecular messengers to adjacent neurons and in this manner executing a steady informational transfer. Glial cells, surrounding neuronal cells, play a crucial role in forming and maintaining the Blood Brain Barrier. Their functions range from homeostatic regulators (astrocytes) to trash collectors (microglia). Like all cells in our body, their specific role is encoded in our DNA and is regulated by gene expression. Nonetheless, small DNA changes (mutations) by cause of internal (inherited) or external (environmental) factors may underlie susceptibility to various disorders, one of which is Parkinson’s Disease (PD). PD is the second most common neurodegenerative disorder, affecting mainly people above the age of 60. More than two centuries have passed since the first medical case was described1 and surprisingly we still don’t have curative treatments. One plausible explanation is the focus of research for many decades on neurons and the lack of understanding of the importance of glia cells (astrocytes and microglia). Continue reading Glial Immune response to hazards in the brain in Parkinson’s Disease

High-Intensity Interval Training Makes You Feel Good Inside Out 

Regular physical activity has great health benefits. An active lifestyle is important to maintain since it is associated with a longer healthspan by delaying the onset of many (chronic) diseases [1]. ‘High-Intensity Interval Training’ (HIIT) is a form of physical activity that, as the name already suggests, involves high-intensity bursts of cardio exercise followed by short periods of recovery. This allows you to maximize your results in building both strength and endurance at the same time. Continue reading High-Intensity Interval Training Makes You Feel Good Inside Out 

The psychedelic “reset” mechanism- and how it could treat depression

In the United States during the 1950s and the 60s, hallucinogenic compounds were widely used recreationally, as well as in research and therapies for mental disorders. A ban on these compounds during the 1960s essentially halted much of the research on these compounds, despite objections from the scientific community, until the 1990s saw a revival on psychedelic research due to eased restrictions. Continue reading The psychedelic “reset” mechanism- and how it could treat depression

Deciphering the developing brain

Diseases can manifest at different stages of life in various parts of the body. But what about the disorders that compromise early development in your brain, the organ that greatly influences your personality, who your friends would be, your sense of self and the general ability to make sense and comprehend the world around you. Neurodevelopmental disorders (NDDs) occur early in life and alter brain function. To understand these disorders, scientists use a variety of tools to unravel how they affect the brain. Continue reading Deciphering the developing brain

Participatory Narrative Inquiry: Using stories to open up science

A bedtime story to tell there are no monsters hiding under your bed, an allegory about norms and morals, or a chat with your colleagues at the coffee machine on Monday morning about what you did last weekend – they all say something. They all give information. I’d like to introduce you to a form of narrative research, also in use by biomedical scientists, which I discovered during my internship. It uses stories to uncover new insights and hypotheses: participatory narrative inquiry (PNI). Continue reading Participatory Narrative Inquiry: Using stories to open up science

Human vs. Mouse: Are Human Cells Smarter?

You can imagine a neuron in the brain’s cortex, or anywhere else in the body, as a city with incoming freight road networks. Neurons have quite a few inward-bound roads (dendrites) packed with freight that receive signals and converge near their city centers (the cell body), but there is always one exit highway (the axon).
To assess characteristic differences between neurons, researchers use neurophysiological measurements such as repetitive firing. It is like assessing how well a city’s infrastructure can handle high amounts of incoming traffic (stimuli) by measuring the speed of the outgoing traffic (APs). Continue reading Human vs. Mouse: Are Human Cells Smarter?

COVID-19 treatment: What we can learn from Lupus

With the global prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2), coronavirus disease 2019 (COVID-19) has affected the lives of billions of people and caused millions of deaths worldwide[1]. How to tame COVID-19 into submission remains quite challenging. But as the old saying goes: all roads lead to Rome, different diseases could share similar pathogenic processes. Continue reading COVID-19 treatment: What we can learn from Lupus

A Glymphatic System: Controversial but Conceivable

Imagine celebrating a huge party at your home. All your friends have attended and brought snacks and booze. After a fun and long night, most of your friends have left. You look around and realize that you are surrounded by empty beer bottles, crumbs of food and even some confetti that seems to have popped out of nowhere. You decide it’s better to tidy up now so that you can wake up in a clean house tomorrow. You and your remaining friends start cleaning right away. While scrubbing, you start wondering, would our brains do the same for us? Continue reading A Glymphatic System: Controversial but Conceivable

Fibrodysplasia Ossificans Progressiva: bone formation outside the skeleton

Fibrodysplasia Ossificans Progressiva (FOP) is a rare, genetic disorder where, slowly, but progressively extra bone formation develops outside the body’s skeleton. A flare-up of new bone formation can be triggered spontaneously or by everyday traumas to the body, such as from falling down stairs or bumping against the kitchen counter. Continue reading Fibrodysplasia Ossificans Progressiva: bone formation outside the skeleton

Can biology save fashion?

The fashion industry is one of the most polluting industries in the world. This is not that surprising if you take into account that it requires more than 7 thousand liters of water and 2kg of carbon dioxide (CO2) to make a single pair of jeans2. To keep up with our increasing demand for clothing 120 million trees are logged yearly, 79 billion cubic meters of water is used and a significant volume of greenhouse gasses are emitted Continue reading Can biology save fashion?

Rocking to the TikTok of your internal body clock

What enables some species to regularly rise with the sun and rest with the stars? The biological mechanism for this is believed to be an evolutionary adaptation to the earth’s 24 hour rotation. It is defined as circadian rhythm and found universally in organisms from cyanobacteria to plants and fruit flies. Continue reading Rocking to the TikTok of your internal body clock

A Living House: Science Fiction or Plausible Future?

We have all seen the pictures of the massive drop in air pollution above China, which is at least partly due to the COVID-19 induced lockdown. China is not alone, as many other countries that are under some form of lockdown have seen decreasing nitrogen dioxide (NO2) levels. Blue skies are now shining above huge concrete skyscrapers and the world is in awe (1). Continue reading A Living House: Science Fiction or Plausible Future?

High-sight: eyeing unanticipated effects of a ‘harmless’ drug

After a long night of partying, Ivan* found himself staring at his reflection in the mirror. Still somewhat intoxicated he didn’t fully comprehend what he saw, or rather, what he did not see: Where his own face should have been staring back at him, he saw a large black void, a sphere of darkness in the center of his visual field…. Continue reading High-sight: eyeing unanticipated effects of a ‘harmless’ drug

LASER ART: Eliminating HIV from the genome

A team of researchers recently claimed to have developed a new treatment to remove all traces of the human immunodeficiency virus (HIV) from the mammalian genome through a combination of using an antiviral drug regime and genetic engineering. Published this summer in Nature Communications, the landmark paper describes how a combination of pre-treating HIV-1 infected mice… Continue reading LASER ART: Eliminating HIV from the genome